Near full-length characterization and population dynamics of the Human Immunodeficiency Virus type I Circulating Recombinant Form 42 (CRF42_BF) in Luxembourg.

  • HIV Clinical and Translational Research
  • Immuno-Pharmacology and Interactomics
May 01, 2015 By:
  • Struck D
  • Roman F
  • De Landtsheer S
  • Servais JY
  • Lambert C
  • Masquelier C
  • Venard V
  • Ruelle J
  • Nijhuis M
  • Schmit JC
  • Seguin-Devaux C.

A new recombinant form representing a mosaic of HIV-1 subtype B and F1 and designated as CRF42_BF was identified in Luxembourg. We confirmed the inedited nature of CRF42_BF by near full-length genome characterization and retrieved a possible ancestor originating from Brazil. The demographic history of CRF42_BF in Luxembourg using Bayesian coalescent-based methods was investigated. The exponential phase of the logistic growth happened in a very short time period of approximately 5 months associated with a high mean rate of population growth of 15.02 new infections per year. However, CRF42_BF was not characterized by either a higher ex vivo replication capacity in peripheral blood mononuclear cells (PBMCs) or a higher ex vivo transmission efficiency from monocyte-derived dendritic cells to PBMCs as compared to B and F1 viruses. These data do not support a high pathogenic potential of CFR42_BF but rather an initial bursting spread of the recombinant probably due to a more favorable transmission route.

2015 May. AIDS Res Hum Retroviruses.31(5):554-8. Epub 2015 Mar 6.
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