High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia.
- Tumor Stroma Interactions
- Tumor Microenvironment
In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.