Hepatitis B virus infection assessed 3 to 18 years after vaccination in Cuban children and adolescents born to HBsAg-positive mothers.

  • Clinical and Applied Virology
  • Vaccinology and B Cell Immunology
August 01, 2017 By:
  • Rodriguez Lay LLA
  • Bello Corredor M
  • Montalvo Villalba MC
  • Chibas Ojeda AG
  • Sariego Frometa S
  • Diaz Gonzalez M
  • Abad Lamoth Y
  • Sanchez Wong M
  • Sausy A
  • Muller CP
  • Hubschen JM.

Thirty-two participants, aged between 3-18 years, born to hepatitis B surface antigen (HBsAg)-positive mothers and vaccinated at birth were analyzed for hepatitis B virus (HBV) infection. Overall, 56% had anti-HB titers >/=10 IU/L; five were positive for antibodies to the core antigen (anti-HBc), and two of these were also positive for HBsAg/DNA. One of the HBsAg/anti-HBc double-negative children presented with an unusual occult infection (HBV DNA-positive). No known vaccine escape mutations were detectable. Our data suggest that the vaccine protected 93.8% of children in this high-risk group against chronic HBV infection. Occult infections should be considered even in countries with low endemicity and high vaccination coverage.

2017 Aug. Arch Virol.162(8):2393-2396. Epub 2017 Apr 24.
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