Chemical constituents of Cassia abbreviata and their anti-2 HIV-1 activity.
- HIV Clinical and Translational Research
Abstract: Three new (1–3) and 25 known compounds were isolated from the crude extract of Cassia 16 abbreviata. The chemical structures of new compounds were established by extensive spectroscopic 17 analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone (1) is the first heterodimer of 18 guibourtinidol and planchol A. Compound 2 was a new chalcane. While 3 was a new naphthalene. 19 Cassiabrevone (1), guibourtinidol-(4α→8)-epiafzelechin (4), taxifolin (8), oleanolic acid (17), 20 piceatannol (22), and palmitic acid (28), exhibited potent anti-HIV-1 activity with IC50 values of 11.89 21 μM, 15.39 μM, 49.04 μM, 7.95 μM, 3.58 μM, 15.97 μM, respectively.