B-cell metabolic remodeling and cancer.

  • Experimental and¬†Molecular Immunology
February 01, 2018 By:
  • Franchina DG
  • Grusdat M
  • Brenner D.

Cells of the immune system display varying metabolic profiles to fulfill their functions. B lymphocytes overcome fluctuating energy challenges as they transition from the resting state and recirculation to activation, rapid proliferation, and massive antibody production. Only through a controlled interplay between metabolism, extracellular stimuli, and intracellular signaling can successful humoral responses be mounted. Alterations to this balance can promote malignant transformation of B cells. The metabolic control of B-cell fate is only partially understood. Here, we provide a compelling overview of the current state of the art and describe the main metabolic features of B cells during normal development and oncogenesis, with emphasis on the major B-cell transcriptional and metabolic regulators, including myelocytomatosis virus oncogene cellular homolog (Myc) and hypoxia-inducible factor 1-alpha (HIF-1alpha).

2018 Feb. Trends Cancer.4(2):138-150. Epub 2018 Feb 1.
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