Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

  • Molecular and Translational Allergology
January 07, 2021 By:
  • Costa J
  • Villa C
  • Verhoeckx K
  • Cirkovic-Velickovic T
  • Schrama D
  • Roncada P
  • Rodrigues PM
  • Piras C
  • Martín-Pedraza L
  • Monaci L
  • Molina E
  • Mazzucchelli G
  • Mafra I
  • Lupi R
  • Lozano-Ojalvo D
  • Larré C
  • Klueber J
  • Gelencser E
  • Bueno-Diaz C
  • Diaz-Perales A
  • Benedé S
  • Bavaro SL
  • Kuehn A
  • Hoffmann-Sommergruber K
  • Holzhauser T.

Key determinants for the development of an allergic response to an otherwise ‘harmless’ food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the intrinsic properties of the allergen, the food matrix (e.g. lipids) and the allergen modification by food processing. Various physicochemical parameters can have an impact on the allergenicity of animal proteins. Following our previous review on how physicochemical parameters shape plant protein allergenicity, the same analysis was proceeded here for animal allergens.

2021 Jan. Clin Rev Allergy Immunol.
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