Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.

  • Clinical and Applied Virology
July 01, 2014 By:
  • Denisova OV
  • Soderholm S
  • Virtanen S
  • Von Schantz C
  • Bychkov D
  • Vashchinkina E
  • Desloovere J
  • Tynell J
  • Ikonen N
  • Theisen LL
  • Nyman TA
  • Matikainen S
  • Kallioniemi O
  • Julkunen I
  • Muller CP
  • Saelens X
  • Verkhusha VV
  • Kainov DE.

The influenza pH1N1 virus caused a global flu pandemic in 2009 and continues manifestation as a seasonal virus. Better understanding of the virus-host cell interaction could result in development of better prevention and treatment options. Here we show that the Akt inhibitor MK2206 blocks influenza pH1N1 virus infection in vitro. In particular, at noncytotoxic concentrations, MK2206 alters Akt signaling and inhibits endocytic uptake of the virus. Interestingly, MK2206 is unable to inhibit H3N2, H7N9, and H5N1 viruses, indicating that pH1N1 evolved specific requirements for efficient infection. Thus, Akt signaling could be exploited further for development of better therapeutics against pH1N1 virus.

2014 Jul. Antimicrob Agents Chemother.58(7):3689-96. Epub 2014 Apr 21.
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