A note regarding meta-analysis of sequential trials with stopping for efficacy.
- Competence Center for Methodology and Statistics
It is shown that fixed-effect meta-analyses of naive treatment estimates from sequentially run trials with the possibility of stopping for efficacy based on a single interim look are unbiassed (or at the very least consistent, depending on the point of view) provided that the trials are weighted by information provided. A simple proof of this is given. An argument is given suggesting that this also applies in the case of multiple looks. The implications for this are discussed.